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轴突通过去细胞肌肉移植物的再生。

Axonal regeneration through acellular muscle grafts.

作者信息

Hall S

机构信息

Division of Anatomy and Cell Biology, UMDS, London, UK.

出版信息

J Anat. 1997 Jan;190 ( Pt 1)(Pt 1):57-71. doi: 10.1046/j.1469-7580.1997.19010057.x.

Abstract

The management of peripheral nerve injury remains a major clinical problem. Progress in this field will almost certainly depend upon manipulating the pathophysiological processes which are triggered by traumatic injuries. One of the most important determinants of functional outcome after the reconstruction of a transected peripheral nerve is the length of the gap between proximal and distal nerve stumps. Long defects (> 2 cm) must be bridged by a suitable conduit in order to support axonal regrowth. This review examines the cellular and acellular elements which facilitate axonal regrowth and the use of acellular muscle grafts in the repair of injuries in the peripheral nervous system.

摘要

周围神经损伤的处理仍然是一个主要的临床问题。该领域的进展几乎肯定取决于对创伤性损伤引发的病理生理过程的调控。横断性周围神经重建术后功能转归的最重要决定因素之一是近端和远端神经残端之间的间隙长度。长节段缺损(>2 cm)必须通过合适的导管进行桥接,以支持轴突再生。本文综述了促进轴突再生的细胞和非细胞成分,以及脱细胞肌肉移植物在周围神经系统损伤修复中的应用。

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