大豆皂苷II对病毒体外复制的抑制活性。

Inhibitory activity of soyasaponin II on virus replication in vitro.

作者信息

Hayashi K, Hayashi H, Hiraoka N, Ikeshiro Y

机构信息

Department of Virology, Toyama Medical and Pharmaceutical University, Japan.

出版信息

Planta Med. 1997 Apr;63(2):102-5. doi: 10.1055/s-2006-957622.

DOI:10.1055/s-2006-957622

PMID:9140220

Abstract

The antiviral activities of two saponins, soyasaponin I and II, isolated from soybean (Glycine max Merrill) were studied in vitro against herpes simplex virus type 1 (HSV-1). Soyasaponin II was more potent than soyasaponin I as shown by reduction of HSV-1 production. Soyasaponin II was also found to inhibit the replication of human cytomegalovirus, influenza virus, and human immunodeficiency virus type 1. The action was not due to inhibition of virus penetration and protein synthesis, but might involve a virucidal effect. When acyclovir and soyasaponin II were evaluated in combination for anti-HSV-1 activity, additive antiviral effects were observed for this virus.

摘要

对从大豆（Glycine max Merrill）中分离出的两种皂苷大豆皂苷I和II的抗病毒活性进行了体外研究，以对抗1型单纯疱疹病毒（HSV-1）。如HSV-1产生量的减少所示，大豆皂苷II比大豆皂苷I更有效。还发现大豆皂苷II可抑制人巨细胞病毒、流感病毒和1型人类免疫缺陷病毒的复制。该作用并非由于抑制病毒穿透和蛋白质合成，而是可能涉及杀病毒作用。当联合评估阿昔洛韦和大豆皂苷II对HSV-1的抗病毒活性时，观察到对该病毒有相加的抗病毒作用。