碘-123-BMIPP显像在不稳定型心绞痛中的应用：介入治疗策略指南

Iodine-123-BMIPP imaging in unstable angina: a guide for interventional strategy.

作者信息

Takeishi Y, Fujiwara S, Atsumi H, Takahashi K, Sukekawa H, Tomoike H

机构信息

First Department of Internal Medicine, Yamagata University School of Medicine, Japan.

出版信息

J Nucl Med. 1997 Sep;38(9):1407-11.

PMID:9293798

Abstract

UNLABELLED

The aim of this study was to clarify the clinical implications of decreased myocardial uptakes of 123I-labeled beta-methyl-p-iodophenyl-pentadecanoic acid (123I-BMIPP) in patients with unstable angina.

METHODS

Fatty acid metabolic imaging with 123I-BMIPP was performed in 20 patients with unstable angina during the pain-free state. Regional uptakes of 123I-BMIPP were scored semiquantitatively, and clinical characteristics and angiographic findings were compared between the patients with the normal and abnormal 123I-BMIPP images.

RESULTS

There were 9 patients with normal and 11 patients with abnormal 123I-BMIPP images. Severe coronary stenosis exceeding 90% (91% compared with 44%, p < 0.05) and 99% (82% compared with 0%, p < 0.01) and collateral opacification (36% compared with 0%, p < 0.05) were more frequently observed in patients with abnormal 123I-BMIPP images than in those with normal images. Percutaneous transluminal coronary angioplasty or coronary artery bypass grafting was performed in 22% of patients with normal 123I-BMIPP images and in 82% of patients with abnormal 123I-BMIPP images (p < 0.01).

CONCLUSION

Fatty acid metabolic imaging with 123I-BMIPP can determine the functional severity of coronary artery disease and is helpful for a clinical judgment in interventional treatment.

摘要

未标注

本研究的目的是阐明不稳定型心绞痛患者心肌对123I标记的β-甲基-对碘苯基十五烷酸（123I-BMIPP）摄取减少的临床意义。

方法

对20例不稳定型心绞痛患者在无痛状态下进行123I-BMIPP脂肪酸代谢成像。对123I-BMIPP的局部摄取进行半定量评分，并比较123I-BMIPP图像正常和异常患者的临床特征及血管造影结果。

结果

123I-BMIPP图像正常的患者有9例，异常的患者有11例。123I-BMIPP图像异常的患者比图像正常的患者更常观察到严重冠状动脉狭窄超过90%（分别为91%和44%，p<0.05）以及99%（分别为82%和0%，p<0.01）和侧支血管显影（分别为36%和0%，p<0.05）。123I-BMIPP图像正常的患者中有22%接受了经皮冠状动脉腔内血管成形术或冠状动脉旁路移植术，而123I-BMIPP图像异常的患者中有82%接受了此类手术（p<0.01）。