白色念珠菌中黏附、丝状生长和毒力与单个基因INT1的关联。

Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1.

作者信息

Gale C A, Bendel C M, McClellan M, Hauser M, Becker J M, Berman J, Hostetter M K

机构信息

Department of Pediatrics, University of Minnesota, 420 Delaware Street S.E., Minneapolis, MN 55455, USA.

出版信息

Science. 1998 Feb 27;279(5355):1355-8. doi: 10.1126/science.279.5355.1355.

DOI:10.1126/science.279.5355.1355

PMID:9478896

Abstract

Adhesion and the ability to form filaments are thought to contribute to the pathogenicity of Candida albicans, the leading cause of fungal disease in immunocompromised patients. Int1p is a C. albicans surface protein with limited similarity to vertebrate integrins. INT1 expression in Saccharomyces cerevisiae was sufficient to direct the adhesion of this normally nonadherent yeast to human epithelial cells. Furthermore, disruption of INT1 in C. albicans suppressed hyphal growth, adhesion to epithelial cells, and virulence in mice. Thus, INT1 links adhesion, filamentous growth, and pathogenicity in C. albicans and Int1p may be an attractive target for the development of antifungal therapies.

摘要

黏附及形成丝状体的能力被认为与白色念珠菌的致病性有关，白色念珠菌是免疫功能低下患者真菌疾病的主要病因。Int1p是一种白色念珠菌表面蛋白，与脊椎动物整合素的相似性有限。在酿酒酵母中表达INT1足以使这种通常不黏附的酵母黏附于人上皮细胞。此外，白色念珠菌中INT1的缺失会抑制菌丝生长、对上皮细胞的黏附以及在小鼠中的毒力。因此，INT1将白色念珠菌的黏附、丝状生长和致病性联系起来，Int1p可能是开发抗真菌疗法的一个有吸引力的靶点。