由在培养中丝状生长存在缺陷的白色念珠菌突变体产生的含有丝状形态的侵袭性病变。
Invasive lesions containing filamentous forms produced by a Candida albicans mutant that is defective in filamentous growth in culture.
作者信息
Riggle P J, Andrutis K A, Chen X, Tzipori S R, Kumamoto C A
机构信息
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
出版信息
Infect Immun. 1999 Jul;67(7):3649-52. doi: 10.1128/IAI.67.7.3649-3652.1999.
Abstract
A Candida albicans efg1 cph1 double mutant is nonfilamentous under standard laboratory conditions and avirulent in mice. However, this mutant produced filaments in the tongues of immunosuppressed gnotobiotic piglets and when embedded in agar, demonstrating that an Efg1p- and Cph1p-independent pathway for promotion of filamentous growth exists.
摘要
白色念珠菌efg1 cph1双突变体在标准实验室条件下不形成菌丝，且对小鼠无致病性。然而，该突变体在免疫抑制的无菌仔猪舌中以及嵌入琼脂时会产生菌丝，这表明存在一条不依赖Efg1p和Cph1p促进丝状生长的途径。
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