Toll样受体在天然免疫应答的诱导过程中。

Toll-like receptors in the induction of the innate immune response.

作者信息

Aderem A, Ulevitch R J

机构信息

Department of Immunology, University of Washington, Seattle 98195, USA.

出版信息

Nature. 2000 Aug 17;406(6797):782-7. doi: 10.1038/35021228.

DOI:10.1038/35021228

PMID:10963608

Abstract

The innate immune response is the first line of defence against infectious disease. The principal challenge for the host is to detect the pathogen and mount a rapid defensive response. A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms. This reflects a remarkable conservation of function and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence.

摘要

先天免疫反应是抵御传染病的第一道防线。宿主面临的主要挑战是检测病原体并迅速做出防御反应。一组构成Toll或Toll样受体家族的蛋白质在脊椎动物和无脊椎动物中发挥这一作用。这反映了功能上的显著保守性，因此，对它们作用机制的研究揭示了宿主防御方面新的重要见解也就不足为奇了。