Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers.
作者信息
Karst H, Karten Y J, Reichardt H M, de Kloet E R, Schütz G, Joëls M
机构信息
Inst. Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands.
出版信息
Nat Neurosci. 2000 Oct;3(10):977-8. doi: 10.1038/79910.
DOI:10.1038/79910
PMID:11017168
Abstract
Glucocorticoids are secreted from the adrenal gland in very high amounts after stress. In the brain, these stress hormones potently modulate ionic currents, monoaminergic transmission, synaptic plasticity and cellular viability, most notably in the hippocampus where corticosteroid receptors are highly enriched. Here we show that at least some of these actions require DNA binding of glucocorticoid receptor (GR) homodimers.
摘要
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