[番荔枝化学成分的研究]

[Studies on the chemical constituents of Annona muricata].

作者信息

Yu J G, Gui H Q, Luo X Z, Sun L, Zhu P, Yu Z L

机构信息

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094.

出版信息

Yao Xue Xue Bao. 1997 Jun;32(6):431-7.

PMID:11596323

Abstract

Annonaceous acetogenin (or polyketide) is a kind of potential antineoplastic agents from Annonaceae plants. Two new acetogenins, Muricatalicin (I) and muricatalin (VI), a mesitoate of a new acetogenin, annonacin-B mesitoate (Vb), and three known acetogenins, annonacin (II), annonacin-A (III) and annonacin-10-one (IV) have been isolated from Annona muricata L. The structures and relative stereochemistry of I, VI and Vb were elucidated on the basis of spectral analysis and examination of their acetates and/or mesitoate.

摘要

番荔枝乙酰精宁（或聚酮化合物）是一类从番荔枝科植物中提取的潜在抗肿瘤药物。从刺果番荔枝中分离出了两种新的乙酰精宁，即刺果番荔枝素（I）和刺果番荔枝苷（VI），一种新乙酰精宁的间苯二甲酸酯，即番荔枝宁 -B间苯二甲酸酯（Vb），以及三种已知的乙酰精宁，即番荔枝宁（II）、番荔枝宁 -A（III）和番荔枝宁 -10-酮（IV）。通过光谱分析以及对它们的乙酸酯和/或间苯二甲酸酯的研究，阐明了I、VI和Vb的结构及相对立体化学。