基因银行
GenBank.
作者信息
Benson Dennis A, Karsch-Mizrachi Ilene, Lipman David J, Ostell James, Rapp Barbara A, Wheeler David L
机构信息
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.
出版信息
Nucleic Acids Res. 2002 Jan 1;30(1):17-20. doi: 10.1093/nar/30.1.17.
The GenBank sequence database incorporates publicly available DNA sequences of more than 105 000 different organisms, primarily through direct submission of sequence data from individual laboratories and large-scale sequencing projects. Most submissions are made using the BankIt (web) or Sequin programs and accession numbers are assigned by GenBank staff upon receipt. Data exchange with the EMBL Data Library and the DNA Data Bank of Japan helps ensure comprehensive worldwide coverage. GenBank data is accessible through NCBI's integrated retrieval system, Entrez, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical literature via PubMed. Sequence similarity searching is provided by the BLAST family of programs. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. NCBI also offers a wide range of World Wide Web retrieval and analysis services based on GenBank data. The GenBank database and related resources are freely accessible via the NCBI home page at http://www.ncbi.nlm.nih.gov.
GenBank序列数据库收录了超过105000种不同生物的公开可用DNA序列，主要通过各个实验室直接提交序列数据以及大规模测序项目来实现。大多数提交是使用BankIt（网络）或Sequin程序进行的，GenBank工作人员在收到数据后会分配登录号。与欧洲分子生物学实验室（EMBL）数据库和日本DNA数据库（DDBJ）的数据交换有助于确保全球范围的全面覆盖。GenBank数据可通过美国国立医学图书馆（NCBI）的综合检索系统Entrez获取，该系统整合了来自主要DNA和蛋白质序列数据库的数据，以及分类学、基因组、图谱、蛋白质结构和结构域信息，还有通过PubMed获取的生物医学文献。序列相似性搜索由BLAST系列程序提供。GenBank数据库每两个月进行一次完整发布，并通过文件传输协议（FTP）进行每日更新。NCBI还基于GenBank数据提供了广泛的万维网检索和分析服务。可通过NCBI主页（http://www.ncbi.nlm.nih.gov）免费访问GenBank数据库及相关资源。
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