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基因库：更新。

GenBank: update.

作者信息

Benson Dennis A, Karsch-Mizrachi Ilene, Lipman David J, Ostell James, Wheeler David L

机构信息

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.

出版信息

Nucleic Acids Res. 2004 Jan 1;32(Database issue):D23-6. doi: 10.1093/nar/gkh045.

DOI:10.1093/nar/gkh045
PMID:14681350
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC308779/
Abstract

GenBank is a comprehensive database that contains publicly available DNA sequences for more than 140 000 named organisms, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects. Most submissions are made using the BankIt (web) or Sequin program and accession numbers are assigned by GenBank staff upon receipt. Daily data exchange with the EMBL Data Library in the UK and the DNA Data Bank of Japan helps ensure worldwide coverage. GenBank is accessible through NCBI's retrieval system, Entrez, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, go to the NCBI home page at: http://www.ncbi.nlm.nih.gov.

摘要

GenBank是一个综合性数据库，包含超过14万个命名生物的公开可用DNA序列，这些序列主要通过各个实验室的提交以及大规模测序项目的批量提交获得。大多数提交是使用BankIt（网络）或Sequin程序进行的，GenBank工作人员在收到提交内容后会分配 accession编号。与英国的EMBL数据库和日本的DNA数据库进行每日数据交换有助于确保全球范围的覆盖。可通过NCBI的检索系统Entrez访问GenBank，该系统整合了来自主要DNA和蛋白质序列数据库的数据，以及分类学、基因组图谱、蛋白质结构和结构域信息，还通过PubMed整合了生物医学期刊文献。BLAST提供对GenBank和其他序列数据库的序列相似性搜索。可通过FTP获得GenBank数据库的完整双月发布版本和每日更新内容。要访问GenBank及其相关的检索和分析服务，请访问NCBI主页：http://www.ncbi.nlm.nih.gov。

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