肝细胞癌中微血管密度与端粒酶活性的关系
Relationship between microvessel density and telomerase activity in hepatocellular carcinoma.
作者信息
Piao Yun-Feng, He Min, Shi Yang, Tang Tong-Yu
机构信息
Department of Gastroenterology, First Hospital of Jilin University, No.1 Xinmin Road, Changchun 130021, Jilin Province, China.
出版信息
World J Gastroenterol. 2004 Jul 15;10(14):2147-9. doi: 10.3748/wjg.v10.i14.2147.
AIM
To study the relationship between microvessel density (MVD), telomerase activity and biological characteristics in hepatocellular carcinoma (HCC).
METHODS
S-P immunohistochemical method and telomeric repeat amplification protocol (TRAP) were respectively used to analyze the MVD and telomerase activity in 58 HCC and adjacent normal tissues.
RESULTS
The MVD in HCC with metastasis, lower differentiation or without intact capsule was significantly higher than that in HCC with intact capsule, higher differentiation, or without metastasis. While MVD had no relationship with tumor size, hepatic virus infection and other clinical factors. Telomerase activity was related to differentiation degree, but not to tumor size or histological grade. MVD in HCC with telomerase activity was higher than that in HCC without telomerase activity.
CONCLUSION
MVD and telomerase activity may serve as diagnostic criteria of HCC in earlier stage. Meanwhile, there may be a cooperative effect between MVD and telomerase on the growth and metastasis of HCC.
目的
研究肝细胞癌（HCC）中微血管密度（MVD）、端粒酶活性与生物学特性之间的关系。
方法
分别采用S-P免疫组织化学法和端粒重复序列扩增法（TRAP）分析58例HCC组织及其癌旁正常组织中的MVD和端粒酶活性。
结果
有转移、低分化或无完整包膜的HCC组织中MVD显著高于有完整包膜、高分化或无转移的HCC组织。而MVD与肿瘤大小、肝病毒感染及其他临床因素无关。端粒酶活性与分化程度有关，但与肿瘤大小或组织学分级无关。有端粒酶活性的HCC组织中MVD高于无端粒酶活性的HCC组织。
结论
MVD和端粒酶活性可能作为HCC早期诊断的标准。同时，MVD和端粒酶在HCC的生长和转移过程中可能存在协同作用。
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