真核生物翻译起始因子4E（eIF4E）抑制蛋白对帽依赖性翻译的调控。

Regulation of cap-dependent translation by eIF4E inhibitory proteins.

作者信息

Richter Joel D, Sonenberg Nahum

机构信息

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

出版信息

Nature. 2005 Feb 3;433(7025):477-80. doi: 10.1038/nature03205.

DOI:10.1038/nature03205

PMID:15690031

Abstract

Eukaryotic messenger RNAs contain a modified guanosine, termed a cap, at their 5' ends. Translation of mRNAs requires the binding of an initiation factor, eIF4E, to the cap structure. Here, we describe a family of proteins that through a shared sequence regulate cap-dependent translation. The biological importance of this translational regulation is immense, and affects such processes as cell growth, development, oncogenic transformation and perhaps even axon pathfinding and memory consolidation.

摘要

真核生物信使核糖核酸（mRNA）在其5'端含有一个经过修饰的鸟苷，称为帽子结构。mRNA的翻译需要起始因子eIF4E与帽子结构结合。在此，我们描述了一类蛋白质，它们通过一个共享序列调节依赖于帽子结构的翻译。这种翻译调控的生物学重要性极大，并影响细胞生长、发育、致癌转化等过程，甚至可能影响轴突导向和记忆巩固。