儿童急性巨核细胞白血病中的MLL-MLLT10融合基因
MLL-MLLT10 fusion gene in pediatric acute megakaryoblastic leukemia.
作者信息
Morerio Cristina, Rapella Annamaria, Tassano Elisa, Rosanda Cristina, Panarello Claudio
机构信息
Dipartimento di Ematologia ed Oncologia Pediatrica, IRCCS Istituto Giannina Gaslini, L.go G. Gaslini 5, 16147 Genova, Italy.
出版信息
Leuk Res. 2005 Oct;29(10):1223-6. doi: 10.1016/j.leukres.2005.03.008. Epub 2005 Apr 11.
The occurrence of MLL gene rearrangement in acute megakaryoblastic leukemia (AML-M7, acute myeloid leukemia, French-American-British type M7) is very rare and limited to pediatric age: in particular, MLL-MLLT10 fusion, previously reported as characteristic of monocytic leukemia, has been reported in only one case of pediatric megakaryoblastic leukemia. We describe the second case with this association in light of the few reported cases of AML-M7 with MLL and/or 11q23 involvement.
MLL基因重排在急性巨核细胞白血病（AML-M7，急性髓系白血病，法美英分型M7）中的发生非常罕见，且仅限于儿童期：特别是，MLL-MLLT10融合基因，之前报道为单核细胞白血病的特征，仅在1例儿童巨核细胞白血病中被报道过。鉴于已报道的少数伴有MLL和/或11q23受累的AML-M7病例，我们描述了第二例存在这种关联的病例。
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