铜（I）催化的甲亚胺叶立德与丙烯酸酯的高度外型选择性和对映选择性[3+2]环加成反应。
Cu(I)-catalyzed highly exo-selective and enantioselective [3 + 2] cycloaddition of azomethine ylides with acrylates.
作者信息
Gao Wenzhong, Zhang Xumu, Raghunath Malati
机构信息
104 Chemistry Building, Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
出版信息
Org Lett. 2005 Sep 15;7(19):4241-4. doi: 10.1021/ol0516925.
PMID:16146397
Abstract
[reaction: see text] A novel Cu(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides with acrylates has been developed. Up to 98/2 exo/endo selectivity and up to 98% enantiomeric excess have been achieved.
摘要
[反应：见正文] 已开发出一种新型的铜（I）催化的甲亚胺叶立德与丙烯酸酯的不对称1,3-偶极环加成反应。已实现高达98/2的外型/内型选择性和高达98%的对映体过量。
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