蝙蝠是类严重急性呼吸综合征冠状病毒的天然宿主。

Bats are natural reservoirs of SARS-like coronaviruses.

作者信息

Li Wendong, Shi Zhengli, Yu Meng, Ren Wuze, Smith Craig, Epstein Jonathan H, Wang Hanzhong, Crameri Gary, Hu Zhihong, Zhang Huajun, Zhang Jianhong, McEachern Jennifer, Field Hume, Daszak Peter, Eaton Bryan T, Zhang Shuyi, Wang Lin-Fa

机构信息

Institute of Zoology, Chinese Academy of Sciences (CAS), Beijing, China.

出版信息

Science. 2005 Oct 28;310(5748):676-9. doi: 10.1126/science.1118391. Epub 2005 Sep 29.

DOI:10.1126/science.1118391

PMID:16195424

Abstract

Severe acute respiratory syndrome (SARS) emerged in 2002 to 2003 in southern China. The origin of its etiological agent, the SARS coronavirus (SARS-CoV), remains elusive. Here we report that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS outbreak. These viruses, termed SARS-like coronaviruses (SL-CoVs), display greater genetic variation than SARS-CoV isolated from humans or from civets. The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak was a member of this coronavirus group.

摘要

严重急性呼吸综合征（SARS）于2002年至2003年在中国南方出现。其病原体严重急性呼吸综合征冠状病毒（SARS-CoV）的起源仍然不明。在此，我们报告蝙蝠种类是与导致SARS爆发的冠状病毒密切相关的冠状病毒的天然宿主。这些病毒被称为类SARS冠状病毒（SL-CoVs），其遗传变异比从人类或果子狸中分离出的SARS-CoV更大。SARS-CoV的人类和果子狸分离株在系统发育上嵌套在SL-CoVs谱系内，表明导致SARS爆发的病毒是该冠状病毒组的成员。