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基于纳米颗粒的药物递送和分子诊断的精准前景。

The pinpoint promise of nanoparticle-based drug delivery and molecular diagnosis.

作者信息

Emerich Dwaine F, Thanos Christopher G

机构信息

LCT BioPharma, Inc., 4 Richmond Square, Providence, RI, United States.

出版信息

Biomol Eng. 2006 Sep;23(4):171-84. doi: 10.1016/j.bioeng.2006.05.026. Epub 2006 Jun 10.

Abstract

Nanotechnology, or systems/device manufacture at the molecular level, is a multidisciplinary scientific field undergoing explosive development. The genesis of nanotechnology can be traced to the promise of revolutionary advances across medicine, communications, genomics and robotics. Without doubt one of the greatest values of nanotechnology will be in the development of new and effective medical treatments (i.e., nanomedicine). This review focuses on the potential of nanomedicine as it specifically relates to (1) the development of nanoparticles for enabling and improving the targeted delivery of therapeutic agents; (2) developing novel and more effective diagnostic and screening techniques to extend the limits of molecular diagnostics providing point-of-care diagnosis and more personalized medicine.

摘要

纳米技术,即分子水平的系统/设备制造,是一个正在经历爆炸式发展的多学科科学领域。纳米技术的起源可以追溯到医学、通信、基因组学和机器人技术等领域有望取得的革命性进展。毫无疑问,纳米技术最大的价值之一将体现在新型有效医疗手段(即纳米医学)的开发上。本综述重点关注纳米医学的潜力,具体涉及:(1)开发纳米颗粒以实现和改善治疗剂的靶向递送;(2)开发新颖且更有效的诊断和筛查技术,以扩展分子诊断的极限,实现即时诊断和更个性化的医疗。

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