癌症的表观基因组学。
The epigenomics of cancer.
作者信息
Jones Peter A, Baylin Stephen B
机构信息
Department of Urology, Biochemistry, and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
出版信息
Cell. 2007 Feb 23;128(4):683-92. doi: 10.1016/j.cell.2007.01.029.
Abstract
Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including stem/precursor cell contributions, and discuss the growing implications of these advances for strategies to control cancer.
摘要
异常的基因功能和改变的基因表达模式是癌症的关键特征。越来越多的证据表明，后天的表观遗传异常与基因改变共同导致了这种失调。在这里，我们综述了在理解表观遗传改变如何参与肿瘤形成的最早阶段（包括干细胞/前体细胞的作用）方面的最新进展，并讨论了这些进展对癌症控制策略日益增加的影响。
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