使用液相色谱法和毛细管电泳法对肾上腺素能药物进行对映体分离技术的最新进展：综述

Recent developments of enantioseparation techniques for adrenergic drugs using liquid chromatography and capillary electrophoresis: a review.

作者信息

Wang Zhenzhen, Ouyang Jin, Baeyens Willy R G

机构信息

College of Chemistry, Beijing Normal University, Beijing 100875, PR China.

出版信息

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 1;862(1-2):1-14. doi: 10.1016/j.jchromb.2007.11.034. Epub 2007 Dec 4.

DOI:10.1016/j.jchromb.2007.11.034

PMID:18164252

Abstract

This review provides the achievements of enantioseparation of adrenergic drugs and application of these methods in clinical and pharmaceutical analysis. The adrenergic agonist and antagonist drugs are analyzed in the direct and indirect modes by liquid chromatography (LC) and capillary electrophoresis (CE). Other chromatographic enantioseparation methods including super- and sub-critical fluid chromatography (SFC), and capillary electrochromatography (CEC) are presented likewise to analyse the cited compounds. The different separation processes for these drugs are briefly discussed and some applications are presented.

摘要

本综述介绍了肾上腺素能药物对映体分离的成果以及这些方法在临床和药物分析中的应用。通过液相色谱（LC）和毛细管电泳（CE）以直接和间接模式分析肾上腺素能激动剂和拮抗剂药物。同样介绍了其他色谱对映体分离方法，包括超临界和亚临界流体色谱（SFC）以及毛细管电色谱（CEC），以分析上述化合物。简要讨论了这些药物的不同分离过程，并介绍了一些应用。