干细胞、多能性的分子调控机制与核重编程
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming.
作者信息
Jaenisch Rudolf, Young Richard
机构信息
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.
出版信息
Cell. 2008 Feb 22;132(4):567-82. doi: 10.1016/j.cell.2008.01.015.
Abstract
Reprogramming of somatic cells to a pluripotent embryonic stem cell-like state has been achieved by nuclear transplantation of a somatic nucleus into an enucleated egg and most recently by introducing defined transcription factors into somatic cells. Nuclear reprogramming is of great medical interest, as it has the potential to generate a source of patient-specific cells. Here, we review strategies to reprogram somatic cells to a pluripotent embryonic state and discuss our understanding of the molecular mechanisms of reprogramming based on recent insights into the regulatory circuitry of the pluripotent state.
摘要
通过将体细胞核移植到去核卵母细胞中，以及最近通过向体细胞中引入特定转录因子，已实现将体细胞重编程为多能胚胎干细胞样状态。核重编程具有重大医学意义，因为它有潜力产生患者特异性细胞来源。在此，我们综述将体细胞重编程为多能胚胎状态的策略，并基于对多能状态调控回路的最新认识，讨论我们对重编程分子机制的理解。
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