好好领会一下！自噬在控制病原体方面的作用。

Digest this! A role for autophagy in controlling pathogens.

作者信息

Whitmarsh Ryan J, Hunter Christopher A

机构信息

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 380 South University Avenue, Philadelphia, PA 19104, USA.

出版信息

Cell Host Microbe. 2008 Nov 13;4(5):413-4. doi: 10.1016/j.chom.2008.10.008.

DOI:10.1016/j.chom.2008.10.008

PMID:18996340

Abstract

Autophagy provides a mechanism for cells to conserve nutrients, but was recently associated with immunity to intracellular pathogens. Here, Zhao et al. (2008) present direct in vivo evidence that autophagy is linked to macrophage control of Toxoplasma gondii and Listeria monocytogenes and highlights that this process intersects with cytokine-mediated antimicrobial responses.

摘要

自噬为细胞提供了一种保存营养物质的机制，但最近它与针对细胞内病原体的免疫反应相关联。在此，赵等人（2008年）提供了直接的体内证据，表明自噬与巨噬细胞对弓形虫和单核细胞增生李斯特菌的控制有关，并强调这一过程与细胞因子介导的抗菌反应相互交叉。