热休克蛋白与衰老
Hsps and aging.
作者信息
Tower John
机构信息
Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089-2910, USA.
出版信息
Trends Endocrinol Metab. 2009 Jul;20(5):216-22. doi: 10.1016/j.tem.2008.12.005. Epub 2009 Apr 24.
Heat-shock proteins (Hsps) are increasingly being implicated in aging phenotypes and control of life span across species. They are targets of the conserved heat-shock factor and insulin/IGF1-like signaling pathways that affect life span and aging phenotypes. Hsps are expressed in tissue-specific and disease-specific patterns during aging, and their level of expression and induction by stress correlates with and, in some instances, predicts life span. In model organisms, Hsps have been shown to increase life span and ameliorate aging-associated proteotoxicity. Finally, Hsps have emerged as key components in regulating aging-related cellular phenotypes, including cell senescence, apoptosis and cancer. The Hsps, therefore, provide a metric of individual stress and aging and are potential targets for interventions in aging and aging-related diseases.
热休克蛋白（Hsps）越来越多地与衰老表型以及跨物种寿命控制相关联。它们是保守的热休克因子和胰岛素/IGF1样信号通路的靶点，这些信号通路会影响寿命和衰老表型。热休克蛋白在衰老过程中以组织特异性和疾病特异性模式表达，其表达水平以及应激诱导情况与寿命相关，在某些情况下还能预测寿命。在模式生物中，热休克蛋白已被证明可延长寿命并改善与衰老相关的蛋白质毒性。最后，热休克蛋白已成为调节衰老相关细胞表型（包括细胞衰老、凋亡和癌症）的关键成分。因此，热休克蛋白提供了个体应激和衰老的衡量指标，并且是衰老及衰老相关疾病干预措施的潜在靶点。
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