Wnt/β-连环蛋白信号传导：组成部分、机制及相关疾病
Wnt/beta-catenin signaling: components, mechanisms, and diseases.
作者信息
MacDonald Bryan T, Tamai Keiko, He Xi
机构信息
F. M. Kirby Neurobiology Center, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Dev Cell. 2009 Jul;17(1):9-26. doi: 10.1016/j.devcel.2009.06.016.
Abstract
Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator beta-catenin controls embryonic development and adult homeostasis. Here we review recent progress in this so-called canonical Wnt signaling pathway. We discuss Wnt ligands, agonists, and antagonists, and their interactions with Wnt receptors. We also dissect critical events that regulate beta-catenin stability, from Wnt receptors to the cytoplasmic beta-catenin destruction complex, and nuclear machinery that mediates beta-catenin-dependent transcription. Finally, we highlight some key aspects of Wnt/beta-catenin signaling in human diseases including congenital malformations, cancer, and osteoporosis, and discuss potential therapeutic implications.
摘要
分泌型糖脂蛋白Wnt家族通过转录共激活因子β-连环蛋白进行信号传导，控制胚胎发育和成人稳态。在此，我们综述了这一所谓经典Wnt信号通路的最新进展。我们讨论了Wnt配体、激动剂和拮抗剂，以及它们与Wnt受体的相互作用。我们还剖析了从Wnt受体到细胞质β-连环蛋白破坏复合物，以及介导β-连环蛋白依赖性转录的核机制中调节β-连环蛋白稳定性的关键事件。最后，我们强调了Wnt/β-连环蛋白信号传导在人类疾病（包括先天性畸形、癌症和骨质疏松症）中的一些关键方面，并讨论了潜在的治疗意义。
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