抗抑郁药的药代动力学和药效学中的性别差异：最新综述。
Sex differences in the pharmacokinetics and pharmacodynamics of antidepressants: an updated review.
作者信息
Bigos Kristin L, Pollock Bruce G, Stankevich Beth A, Bies Robert R
机构信息
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
Gend Med. 2009 Dec;6(4):522-43. doi: 10.1016/j.genm.2009.12.004.
BACKGROUND
An increasing number of studies have reported differences in the pharmacokinetics and/or pharmacodynamics of antidepressants between women and men.
OBJECTIVES
This article updates previously published literature describing sex differences in the pharmacokinetics and pharmacodynamics of antidepressants, and examines specific issues that face women with psychiatric illness.
METHODS
An English-language literature search was performed with the PubMed database (March 2003-December 2008) using combinations of the search terms sex, gender, and antidepressants. In addition, each antidepressant was identified in the 63rd edition of the Physicians' Desk Reference.
RESULTS
The current data suggest that the pharmacokinetics of antidepressants can be substantially different between women and men. Likewise, the response to antidepressants can be quite variable, including sex differences in adverse effects and time to response.
CONCLUSIONS
Despite the many sex differences reported, there is still little published work systematically evaluating potential sex differences in antidepressant pharmacokinetics and pharmacodynamics. More research is needed to guide the treatment of depression and other mental illnesses.
背景
越来越多的研究报告了抗抑郁药在女性和男性之间的药代动力学和/或药效动力学差异。
目的
本文更新了先前发表的描述抗抑郁药药代动力学和药效动力学性别差异的文献，并探讨了患有精神疾病的女性所面临的具体问题。
方法
使用“性别”“性”和“抗抑郁药”等搜索词组合，在PubMed数据库（2003年3月至2008年12月）中进行了英文文献检索。此外，在《医师案头参考》第63版中对每种抗抑郁药进行了识别。
结果
目前的数据表明，抗抑郁药在女性和男性之间的药代动力学可能有很大差异。同样，对抗抑郁药的反应也可能差异很大，包括不良反应和起效时间方面的性别差异。
结论
尽管报告了许多性别差异，但仍很少有发表的工作系统地评估抗抑郁药药代动力学和药效动力学中潜在的性别差异。需要更多的研究来指导抑郁症和其他精神疾病的治疗。
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