未能从精神科患者的外周血单个核细胞中检测到博尔纳病病毒抗体和 RNA。
Failure to detect borna disease virus antibody and RNA from peripheral blood mononuclear cells of psychiatric patients.
机构信息
Department of Psychiatry, College of Medicine, Korea University, Seoul, Korea.
出版信息
Psychiatry Investig. 2009 Dec;6(4):306-12. doi: 10.4306/pi.2009.6.4.306. Epub 2009 Nov 5.
Abstract
OBJECTIVE
Borna disease virus (BDV) is a highly neurotropic agent causing various neuropsychiatric symptoms in animals. Over the past two decades, it has been suggested that BDV might be associated with human psychiatric diseases. We aimed to investigate whether BDV is associated with psychiatric patients in Korea.
METHODS
We recruited 60 normal controls and 198 psychiatric patients (98 patients with depressive disorder, 60 with schizophrenia, and 40 with bipolar disorder). We used an indirect immunofluorescence antibody (IFA) test for the BDV antibody and a real-time reverse transcriptase polymerase chain reaction (rRT-PCR) assay for p24 and p40 RNA from peripheral blood mononuclear cells (PBMCs).
RESULTS
Neither the BDV antibody nor p24, p40 RNA was detected in controls and patients groups.
CONCLUSION
Our results suggest that BDV might not be associated with psychiatric patients in Korea.
摘要
目的
博尔纳病病毒（BDV）是一种高度嗜神经病原体，可导致动物出现各种神经精神症状。在过去的二十年中，有人提出BDV 可能与人类精神疾病有关。我们旨在调查 BDV 是否与韩国的精神科患者有关。
方法
我们招募了 60 名正常对照者和 198 名精神科患者（98 名抑郁症患者，60 名精神分裂症患者和 40 名双相情感障碍患者）。我们使用间接免疫荧光抗体（IFA）试验检测 BDV 抗体，并用实时逆转录聚合酶链反应（rRT-PCR）检测外周血单个核细胞（PBMC）中的 p24 和 p40 RNA。
结果
对照组和患者组均未检测到 BDV 抗体和 p24、p40 RNA。
结论
我们的结果表明，BDV 可能与韩国的精神科患者无关。
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