感染因子与抑郁症的荟萃分析。
Meta-analysis of infectious agents and depression.
作者信息
Wang Xiao, Zhang Liang, Lei Yang, Liu Xia, Zhou Xinyu, Liu Yiyun, Wang Mingju, Yang Liu, Zhang Lujun, Fan Songhua, Xie Peng
机构信息
1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3].
1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [4].
出版信息
Sci Rep. 2014 Mar 31;4:4530. doi: 10.1038/srep04530.
Depression is a debilitating psychiatric disorder and a growing global public health issue. However, the relationships between microbial infections and depression remains uncertain. A computerized literature search of Medline, ISI Web of Knowledge, PsycINFO, and the Cochrane Library was conducted up to May 2013, and 6362 studies were initially identified for screening. Case-control studies detected biomarker of microorganism were included. Based on inclusion and exclusion criteria, 28 studies were finally included to compare the detection of 16 infectious agents in unipolar depressed patients and healthy controls with a positive incident being defined as a positive biochemical marker of microbial infection. A customized form was used for data extraction. Pooled analysis revealed that the majority of the 16 infectious agents were not significantly associated with depression. However, there were statistically significant associations between depression and infection with Borna disease virus, herpes simplex virus-1, varicella zoster virus, Epstein-Barr virus, and Chlamydophila trachomatis.
抑郁症是一种使人衰弱的精神障碍，且是一个日益严重的全球公共卫生问题。然而，微生物感染与抑郁症之间的关系仍不明确。截至2013年5月，对医学文献数据库（Medline）、科学网（ISI Web of Knowledge）、心理学文摘数据库（PsycINFO）和考克兰图书馆进行了计算机化文献检索，最初识别出6362项研究以供筛选。纳入检测微生物生物标志物的病例对照研究。根据纳入和排除标准，最终纳入28项研究，以比较单相抑郁症患者和健康对照中16种感染因子的检测情况，阳性事件定义为微生物感染的阳性生化标志物。使用定制表格进行数据提取。汇总分析显示，16种感染因子中的大多数与抑郁症无显著关联。然而，抑郁症与博尔纳病病毒、单纯疱疹病毒1型、水痘带状疱疹病毒、爱泼斯坦-巴尔病毒和沙眼衣原体感染之间存在统计学上的显著关联。
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