载脂蛋白 E-epsilon4 和 -epsilon2 在上海遗忘型轻度认知障碍和痴呆中的作用：SCOBHI-P。
Effects of apolipoprotein E-epsilon4 and -epsilon2 in amnestic mild cognitive impairment and dementia in Shanghai: SCOBHI-P.
机构信息
Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612, USA.
出版信息
Am J Alzheimers Dis Other Demen. 2010 May;25(3):233-8. doi: 10.1177/1533317509357736. Epub 2010 Feb 8.
OBJECTIVE
To determine apolipoprotein E (APOE)-epsilon4 and -epsilon2 frequencies and risk of mild cognitive impairment (MCI) and dementia in Shanghai, China.
METHODS
A total of 34 MCI and 34 dementia cases were recruited from an urban Memory Disorders Clinic and 32 controls were recruited from a residential community served by the clinic. Apolipoprotein E was genotyped using standard methods.
RESULTS
Among controls, frequencies were epsilon2, 0.11; epsilon3, 0.84; and epsilon4, 0.05; among MCI, 0.05, 0.77, and 0.18; and for dementia, 0.02, 0.84, and 0.15, respectively. In education-adjusted models, the odds ratio (OR) = 5.6 for dementia (95% CI = 1.09-29.3) and 4.7 for MCI (95% CI = 0.90-25.2) associated with any epsilon4 allele. The epsilon2 allele was inversely associated with dementia (OR = 0.12, 95% CI = 0.013-0.997) and MCI (OR = 0.38, 95% CI = 0.08-1.61).
CONCLUSIONS
APOE-epsilon4 increases and -epsilon2 decreases the risk of dementia vs normal cognition. Similar trends were observed for amnestic mild cognitive impairment (aMCI).
目的
在中国上海，确定载脂蛋白 E（APOE）-ε4 和 -ε2 的频率以及发生轻度认知障碍（MCI）和痴呆的风险。
方法
共从城市记忆障碍诊所招募了 34 例 MCI 和 34 例痴呆病例，从诊所服务的居民区招募了 32 名对照。采用标准方法对载脂蛋白 E 进行基因分型。
结果
在对照组中，频率分别为 ε2，0.11；ε3，0.84；和 ε4，0.05；在 MCI 中，频率分别为 0.05、0.77 和 0.18；在痴呆组中，频率分别为 0.02、0.84 和 0.15。在经过教育调整的模型中，痴呆的比值比（OR）=5.6（95%CI=1.09-29.3），MCI 的 OR=4.7（95%CI=0.90-25.2）与任何 ε4 等位基因相关。ε2 等位基因与痴呆（OR=0.12，95%CI=0.013-0.997）和 MCI（OR=0.38，95%CI=0.08-1.61）呈负相关。
结论
APOE-ε4 增加，而 -ε2 降低了认知正常与痴呆的风险。遗忘型轻度认知障碍（aMCI）也出现了类似的趋势。
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