一项更新的荟萃分析：载脂蛋白E基因分型与原发性开角型青光眼的风险
An updated meta-analysis: apolipoprotein E genotypes and risk of primary open-angle glaucoma.
作者信息
Liao Rongfeng, Ye Minjie, Xu Xiping
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China ; Department of Ophthalmology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Department of Ophthalmology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
出版信息
Mol Vis. 2014 Jul 19;20:1025-36. eCollection 2014.
PURPOSE
To study the association of apolipoprotein E (APOE) polymorphisms and primary open-angle glaucoma (POAG).
METHODS
After a systematic literature search, all relevant studies evaluating the association between APOE polymorphisms and POAG were included. All statistical tests were calculated with Stata 11.0.
RESULTS
Twelve independent studies on the APOE gene (1,971 cases, 1,756 controls) and POAG were included. A significant association between the APOE gene and POAG was found in the genetic model of ε4/ε4 versus ε3/ε3 (odds ratio [OR] = 2.09, 95% confidence interval [CI] = 1.12-3.88, p = 0.02). However, no association was detected in the models of ε2/ε2 versus ε3/ε3, ε2/ε3 versus ε3/ε3, ε2/ε4 versus ε3/ε3, ε3/ε4 versus ε3/ε3, allele ε2 versus allele ε3, and allele ε4 versus allele ε3. Subgroup analyses showed that a statistically significant association between the APOE gene and the risk of POAG existed in the genetic model of ε4/ε4 versus ε3/ε3 in Asians (OR = 3.55, 95% CI = 1.06-11.87, p = 0.04). No association was identified between the APOE gene and the risk of POAG in Caucasians.
CONCLUSIONS
The present meta-analysis indicated that the ε4/ε4 genotype is associated with increased risk of POAG in Asians.
目的
研究载脂蛋白E（APOE）基因多态性与原发性开角型青光眼（POAG）之间的关联。
方法
在进行系统的文献检索后，纳入了所有评估APOE基因多态性与POAG之间关联的相关研究。所有统计检验均使用Stata 11.0进行计算。
结果
纳入了12项关于APOE基因（1971例病例，1756例对照）与POAG的独立研究。在ε4/ε4与ε3/ε3的遗传模型中发现APOE基因与POAG之间存在显著关联（优势比[OR]=2.09，95%置信区间[CI]=1.12 - 3.88，p = 0.02）。然而，在ε2/ε2与ε3/ε3、ε2/ε3与ε3/ε3、ε2/ε4与ε3/ε3、ε3/ε4与ε3/ε3、等位基因ε2与等位基因ε3以及等位基因ε4与等位基因ε3的模型中未检测到关联。亚组分析表明，在亚洲人的ε4/ε4与ε3/ε3遗传模型中，APOE基因与POAG风险之间存在统计学显著关联（OR = 3.55，95% CI = 1.06 - 11.87，p = 0.04）。在白种人中未发现APOE基因与POAG风险之间存在关联。
结论
本荟萃分析表明，ε4/ε4基因型与亚洲人患POAG的风险增加有关。
Zotero 插件