干细胞与龛：一对动态组合。
Stem cells and the niche: a dynamic duo.
机构信息
Laboratory of Genetics, The Salk Institute for Biological Studies, University of California, San Diego, La Jolla, CA 92037, USA.
出版信息
Cell Stem Cell. 2010 Feb 5;6(2):103-15. doi: 10.1016/j.stem.2010.01.011.
Abstract
Stem cell niches are dynamic microenvironments that balance stem cell activity to maintain tissue homeostasis and repair throughout the lifetime of an organism. The development of strategies to monitor and perturb niche components has provided insight into the responsive nature of the niche and offers a framework to uncover how disruption of normal stem cell niche function may contribute to aging and disease onset and progression. Additional work in the identification of genetic factors that regulate the formation, activity, and size of stem cell niches will facilitate incorporation of the niche into stem cell-based therapies and regenerative medicine.
摘要
干细胞龛是动态的微环境，可平衡干细胞活性，以维持组织内稳态并在整个生物体的生命周期中进行修复。开发监测和干扰龛成分的策略为了解龛的响应性质提供了线索，并为揭示正常干细胞龛功能的破坏如何导致衰老和疾病的发生和进展提供了框架。在鉴定调节干细胞龛形成、活性和大小的遗传因素方面的进一步研究将有助于将龛纳入基于干细胞的治疗和再生医学。
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