胃肠道疾病患者口服特定脂肪酸后红细胞膜磷脂脂肪酸组成的变化。
Change in the fatty acid pattern of erythrocyte membrane phospholipids after oral supplementation of specific fatty acids in patients with gastrointestinal diseases.
机构信息
Department of Urology, Medical Nutrition Science, University of Bonn, Bonn, Germany.
出版信息
Eur J Clin Nutr. 2010 Apr;64(4):410-8. doi: 10.1038/ejcn.2009.151. Epub 2010 Feb 17.
BACKGROUND/OBJECTIVES: The fatty acid pattern of membrane phospholipids is suggested to affect membrane fluidity and epithelial barrier function as a result of membrane fatty acid unsaturation. The incorporation of n-3 polyunsaturated fatty acids (PUFAs) into membrane phospholipids may diminish inflammatory potential in patients with gastrointestinal diseases. The aim of this study was to improve the fatty acid profile of erythrocyte membrane phospholipids after oral supplementation of specific fatty acids in patients with maldigestion and/or malabsorption.
SUBJECTS/METHODS: We conducted a randomized, double-blind, controlled trial. A total of 48 patients with gastrointestinal diseases received either fat-soluble vitamins A,D,E,K (ADEK) or ADEK plus fatty acids alpha-linolenic acid (ALA), docosahexaenoic acid (DHA) and medium-chain triglycerides (FA-ADEK) for 12 weeks. The fatty acid profile of erythrocyte membrane phospholipids, dietary intake, plasma antioxidant vitamins and serum gamma-glutamyl transferase (GGT) were evaluated at baseline, 8 and 12 weeks after supplementation.
RESULTS
Supplementation with FA-ADEK increased ALA, DHA and eicosapentaenoic acid (EPA) concentrations of erythrocyte membrane phospholipids by 0.040, 1.419 and 0.159%, respectively, compared with ADEK supplementation (-0.007, 0.151 and 0.002%, respectively) after 12 weeks (all P<or=0.001). Serum GGT activity decreased in patients receiving FA-ADEK compared with those receiving ADEK with a significant difference after 8 weeks.
CONCLUSIONS
The significant change in erythrocyte membrane fatty acid pattern demonstrates the incorporation of orally administered n-3 PUFA in patients with maldigestion and malabsorption. The increase in ALA and DHA, as well as the conversion of ALA to EPA is attributed to the supplementation of sufficient amounts of ALA and DHA, respectively. Serum GGT activity decreased in response to decreased oxidative stress.
背景/目的：细胞膜磷脂的脂肪酸模式被认为会影响膜流动性和上皮屏障功能，这是由于膜脂肪酸不饱和的结果。将 n-3 多不饱和脂肪酸（PUFA）纳入细胞膜磷脂可能会降低胃肠道疾病患者的炎症潜力。本研究的目的是通过口服补充特定脂肪酸来改善消化不良和/或吸收不良患者的红细胞膜磷脂脂肪酸谱。
受试者/方法：我们进行了一项随机、双盲、对照试验。共有 48 名胃肠道疾病患者接受脂溶性维生素 A、D、E、K（ADEK）或 ADEK 加脂肪酸 α-亚麻酸（ALA）、二十二碳六烯酸（DHA）和中链甘油三酯（FA-ADEK）治疗，为期 12 周。在基线、补充 8 周和 12 周后，评估红细胞膜磷脂的脂肪酸谱、膳食摄入、血浆抗氧化维生素和血清 γ-谷氨酰转移酶（GGT）。
结果
与 ADEK 补充剂相比（分别为-0.007、0.151 和 0.002%），FA-ADEK 补充剂在 12 周后使红细胞膜磷脂中的 ALA、DHA 和二十碳五烯酸（EPA）浓度分别增加了 0.040、1.419 和 0.159%（均 P<0.001）。与接受 ADEK 治疗的患者相比，接受 FA-ADEK 治疗的患者的血清 GGT 活性在 8 周后下降，差异具有统计学意义。
结论
红细胞膜脂肪酸模式的显著变化表明，口服给予 n-3 PUFA 可被消化不良和吸收不良的患者吸收。ALA 和 DHA 的增加以及 ALA 向 EPA 的转化归因于分别补充足够量的 ALA 和 DHA。血清 GGT 活性的降低与氧化应激的减少有关。
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