从造血祖细胞到 B 细胞：谱系限制和定向的机制。
From hematopoietic progenitors to B cells: mechanisms of lineage restriction and commitment.
机构信息
Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA.
出版信息
Curr Opin Immunol. 2010 Apr;22(2):177-84. doi: 10.1016/j.coi.2010.02.003. Epub 2010 Mar 6.
Abstract
The generation of B lymphocytes from hematopoietic progenitors requires lineage-specific transcription factors that progressively direct cell fate choices. Differentiation of hematopoietic stem cells to lymphoid progenitors requires Ikaros-dependent lineage priming and graded levels of PU.1, which are controlled by Ikaros and Gfi1. E2A drives expression of EBF1, which initiates B lineage specification. EBF1, in addition to Pax5, is necessary for commitment to the B cell lineage. As a model of gene activation in early B lymphopoiesis, mb-1 genes are activated sequentially by factors (e.g. EBF1) that initiate chromatin modifications before transcription. This review highlights the requisite interplay between transcription factors and epigenetic mechanisms in the context of B cell development.
摘要
B 淋巴细胞由造血祖细胞生成，需要特异性转录因子来逐步指导细胞命运选择。造血干细胞向淋巴样祖细胞的分化需要依赖 Ikaros 的谱系启动和逐渐增加的 PU.1 水平，这由 Ikaros 和 Gfi1 控制。E2A 驱动 EBF1 的表达，从而启动 B 细胞谱系的特异性。EBF1 与 Pax5 一起，对于 B 细胞谱系的确定是必需的。作为早期 B 淋巴细胞发生中基因激活的模型，mb-1 基因被（如 EBF1）等因子依次激活，这些因子在转录前引发染色质修饰。本综述强调了转录因子和表观遗传机制在 B 细胞发育过程中的必要相互作用。
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