鉴定诺如病毒为成人急性肠胃炎病例中检出的主要肠病毒。
Identification of norovirus as the top enteric viruses detected in adult cases with acute gastroenteritis.
机构信息
Department of Epidemiology, Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, People's Republic of China.
出版信息
Am J Trop Med Hyg. 2010 Apr;82(4):717-22. doi: 10.4269/ajtmh.2010.09-0491.
To elucidate the importance of the norovirus and other enteric viruses, and the difference of the genetic relatedness on norovirus between the outbreak and sporadic cases, a total of 557 stool samples, consisting of 503 sporadic cases and 54 samples of 4 outbreaks were collected and tested for norovirus and other enteric viruses in Beijing, China, July 2007-June 2008. The data showed norovirus, rotavirus, astrovirus, and sapovirus, were detected in 26.6%, 6.1%, 1.8%, and 0.5%, respectively. Norovirus was detected almost throughout the surveillance period, norovirus co-infecting with rotavirus, astrovirus, and sapovirus, respectively, were identified both in outbreak and the sporadic cases. GII.4/2006 was identified as the predominant strain circulating both in outbreak and sporadic cases. The results showed that norovirus was rather the important agent than other enteric viruses affected adults with acute gastroenteritis; no significant genetic relatedness of the dominant strains was found between the outbreak and sporadic cases.
为了阐明诺如病毒和其他肠道病毒的重要性，以及暴发和散发病例之间诺如病毒遗传相关性的差异，我们于 2007 年 7 月至 2008 年 6 月在中国北京采集了 557 份粪便样本，包括 503 份散发病例和 54 份 4 起暴发的样本，用于检测诺如病毒和其他肠道病毒。结果显示，诺如病毒、轮状病毒、星状病毒和肠型杯状病毒的检出率分别为 26.6%、6.1%、1.8%和 0.5%。诺如病毒几乎在整个监测期间都有检出，在暴发和散发病例中均发现了诺如病毒与轮状病毒、星状病毒和肠型杯状病毒的混合感染。GII.4/2006 被鉴定为暴发和散发病例中流行的主要毒株。结果表明，诺如病毒是导致成人急性胃肠炎的重要病原体，而非其他肠道病毒；暴发和散发病例中主要流行株之间没有明显的遗传相关性。
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