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大麦黄花叶病毒样无帽依赖性翻译元件在四种植物病毒 RNA 属中的结构可塑性。

Structural plasticity of Barley yellow dwarf virus-like cap-independent translation elements in four genera of plant viral RNAs.

机构信息

Department of Plant Pathology, 351 Bessey Hall, Iowa State University, Ames, IA 50011, USA.

出版信息

Virology. 2010 Jun 20;402(1):177-86. doi: 10.1016/j.virol.2010.03.025. Epub 2010 Apr 13.

DOI:10.1016/j.virol.2010.03.025
PMID:20392470
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2905845/
Abstract

The 3' untranslated regions (UTRs) of many plant viral RNAs contain cap-independent translation elements (3' CITEs). Among the 3' CITEs, the Barley yellow dwarf virus (BYDV)-like translation elements (BTEs) form a structurally variable and widely distributed group. Viruses in three genera were known to harbor 3' BTEs, defined by the presence of a 17-nt consensus sequence. To understand BTE function, knowledge of phylogenetically conserved structure is essential, yet the secondary structure has been determined only for the BYDV BTE. Here we show that Rose spring dwarf-associated luteovirus, and two viruses in a fourth genus, Umbravirus, contain functional BTEs, despite deviating in the 17nt consensus sequence. Structure probing by selective 2'-hydroxyl acylation and primer extension (SHAPE) revealed conserved and highly variable structures in BTEs in all four genera. We conclude that BTEs tolerate striking evolutionary plasticity in structure, while retaining the ability to stimulate cap-independent translation.

摘要

许多植物病毒 RNA 的 3'非翻译区（UTR）含有非帽子依赖性翻译元件（3'CITEs）。在 3'CITEs 中，大麦黄花叶病毒（BYDV）样翻译元件（BTEs）形成了一个结构可变且广泛分布的群体。已知三个属的病毒都含有 3' BTEs，其特征是存在 17 个核苷酸的保守序列。为了了解 BTE 的功能，必须了解系统发育上保守的结构，但 BYDV BTE 的二级结构仅被确定。在这里，我们表明，玫瑰春矮缩相关黄花叶病毒，以及第四个属中的两种病毒，含有功能 BTEs，尽管在 17nt 保守序列中存在差异。通过选择性 2'-羟基酰化和引物延伸（SHAPE）进行结构探测，揭示了所有四个属的 BTEs 中保守和高度可变的结构。我们得出结论，BTEs 在结构上容忍了惊人的进化可塑性，同时保留了刺激非帽子依赖性翻译的能力。

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本文引用的文献

1
The mechanism of eukaryotic translation initiation and principles of its regulation.
Nat Rev Mol Cell Biol. 2010 Feb;11(2):113-27. doi: 10.1038/nrm2838.
2
Host-dependent roles of the viral 5' untranslated region (UTR) in RNA stabilization and cap-independent translational enhancement mediated by the 3' UTR of Red clover necrotic mosaic virus RNA1.
Virology. 2009 Aug 15;391(1):107-18. doi: 10.1016/j.virol.2009.05.037. Epub 2009 Jul 4.
3
Toward a structural understanding of IRES RNA function.
Curr Opin Struct Biol. 2009 Jun;19(3):267-76. doi: 10.1016/j.sbi.2009.03.005. Epub 2009 Apr 9.
4
Structure of a viral cap-independent translation element that functions via high affinity binding to the eIF4E subunit of eIF4F.
J Biol Chem. 2009 May 22;284(21):14189-202. doi: 10.1074/jbc.M808841200. Epub 2009 Mar 10.
5
The 3' proximal translational enhancer of Turnip crinkle virus binds to 60S ribosomal subunits.
RNA. 2008 Nov;14(11):2379-93. doi: 10.1261/rna.1227808. Epub 2008 Sep 29.
6
Mechanism of plant eIF4E-mediated resistance against a Carmovirus (Tombusviridae): cap-independent translation of a viral RNA controlled in cis by an (a)virulence determinant.
Plant J. 2008 Dec;56(5):716-27. doi: 10.1111/j.1365-313X.2008.03630.x. Epub 2008 Jul 19.
7
Rose spring dwarf-associated virus has RNA structural and gene-expression features like those of Barley yellow dwarf virus.
Virology. 2008 Jun 5;375(2):354-60. doi: 10.1016/j.virol.2008.01.035. Epub 2008 Mar 7.
8
The amazing diversity of cap-independent translation elements in the 3'-untranslated regions of plant viral RNAs.
Biochem Soc Trans. 2007 Dec;35(Pt 6):1629-33. doi: 10.1042/BST0351629.
9
The 3' cap-independent translation element of Barley yellow dwarf virus binds eIF4F via the eIF4G subunit to initiate translation.
RNA. 2008 Jan;14(1):134-47. doi: 10.1261/rna.777308. Epub 2007 Nov 19.
10
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