雌激素与精子发生。
Oestrogens and spermatogenesis.
机构信息
Department of Biochemistry, University of Caen, EA 2608, USC 2006 INRA, IFR 146, 14032 Caen, France.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2010 May 27;365(1546):1517-35. doi: 10.1098/rstb.2009.0235.
Abstract
The role of oestrogens in male reproductive tract physiology has for a long time been a subject of debate. The testis produces significant amounts of oestrogenic hormones, via aromatase, and oestrogen receptors (ERs)alpha (ESR1) and ERbeta (ESR2) are selectively expressed in cells of the testis as well as the epididymal epithelium, depending upon species. This review summarizes the current knowledge concerning the presence and activity of aromatase and ERs in testis and sperm and the potential roles that oestrogens may have in mammalian spermatogenesis. Data show that physiology of the male gonad is in part under the control of a balance of androgens and oestrogens, with aromatase serving as a modulator.
摘要
雌激素在男性生殖道生理学中的作用长期以来一直是一个争论的话题。睾丸通过芳香酶产生大量的雌激素激素，雌激素受体（ERs）alpha（ESR1）和 ERbeta（ESR2）在物种上选择性地表达在睾丸和附睾上皮细胞中。这篇综述总结了目前关于芳香酶和 ERs 在睾丸和精子中的存在和活性以及雌激素在哺乳动物精子发生中可能发挥的作用的知识。数据表明，男性性腺的生理学部分受雄激素和雌激素平衡的控制，芳香酶作为一种调节剂。
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