miRNA 网络中的遗传变异：对癌症研究的影响。
Genetic variation in microRNA networks: the implications for cancer research.
机构信息
Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Building 37, Room 3068A, Bethesda, MD 20892-4258, USA.
出版信息
Nat Rev Cancer. 2010 Jun;10(6):389-402. doi: 10.1038/nrc2867.
Abstract
Many studies have highlighted the role that microRNAs have in physiological processes and how their deregulation can lead to cancer. More recently, it has been proposed that the presence of single nucleotide polymorphisms in microRNA genes, their processing machinery and target binding sites affects cancer risk, treatment efficacy and patient prognosis. In reviewing this new field of cancer biology, we describe the methodological approaches of these studies and make recommendations for which strategies will be most informative in the future.
摘要
许多研究都强调了 microRNAs 在生理过程中的作用，以及它们的失调如何导致癌症。最近，有人提出，microRNA 基因、其加工机制和靶结合位点中单核苷酸多态性的存在会影响癌症风险、治疗效果和患者预后。在回顾癌症生物学这一新领域时，我们描述了这些研究的方法学方法，并就未来最具信息性的策略提出了建议。
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