评估香芹酚对白色念珠菌菌株的体外活性。

Evaluation of in vitro activity of carvacrol against Candida albicans strains.

机构信息

Department of Microbiology, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey.

出版信息

Nat Prod Res. 2010 Jul;24(12):1189-93. doi: 10.1080/14786410903565184.

PMID:20582812

Abstract

In this study, the in vitro activity of carvacrol on 100 clinical isolates of Candida albicans was evaluated by determining the minimum inhibitory concentrations (MICs). Susceptibility of clinical isolates of C. albicans to carvacrol was determined by broth microdilution method. Carvacrol was active in vitro against all strains of C. albicans, with MICs ranging from 0.125% to 0.004%. MIC(50) and MIC(90) values of carvacrol were observed at 0.064 and 0.125 mg mL(-1), respectively. MIC and MFC values were similar for most of the tested strains. These results indicated that carvacrol inhibited the growth of C. albicans, implying its potential use in the topical treatment of C. albicans infections.

摘要

在这项研究中，通过测定最低抑菌浓度（MIC）评估香芹酚对 100 株临床分离白念珠菌的体外活性。采用肉汤微量稀释法测定临床分离白念珠菌对香芹酚的敏感性。香芹酚对所有白念珠菌菌株均具有体外活性，MIC 范围为 0.125%至 0.004%。香芹酚的 MIC50 和 MIC90 值分别为 0.064 和 0.125mg/ml。对于大多数测试菌株，MIC 和 MFC 值相似。这些结果表明香芹酚抑制了白念珠菌的生长，这意味着它可能用于局部治疗白念珠菌感染。