视黄醇途径与癌症治疗学。
Retinoid pathway and cancer therapeutics.
机构信息
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
出版信息
Adv Drug Deliv Rev. 2010 Oct 30;62(13):1285-98. doi: 10.1016/j.addr.2010.07.003. Epub 2010 Aug 3.
Abstract
The retinoids are a class of compounds that are structurally related to vitamin A. Retinoic acid, which is the active metabolite of retinol, regulates a wide range of biological processes including development, differentiation, proliferation, and apoptosis. Retinoids exert their effects through a variety of binding proteins including cellular retinol-binding protein (CRBP), retinol-binding proteins (RBP), cellular retinoic acid-binding protein (CRABP), and nuclear receptors i.e. retinoic acid receptor (RAR) and retinoid x receptor (RXR). Because of the pleiotropic effects of retinoids, understanding the function of these binding proteins and nuclear receptors assists us in developing compounds that have specific effects. This review summarizes our current understanding of how retinoids are processed and act with an emphasis on the application of retinoids in cancer treatment and prevention.
摘要
类视黄醇是一大类与维生素 A 结构相关的化合物。视黄酸是视黄醇的活性代谢物，可调节包括发育、分化、增殖和凋亡在内的多种生物学过程。类视黄醇通过多种结合蛋白发挥作用，包括细胞视黄醇结合蛋白（CRBP）、视黄醇结合蛋白（RBP）、细胞视黄酸结合蛋白（CRABP）和核受体，即视黄酸受体（RAR）和视黄醛 X 受体（RXR）。由于类视黄醇的多效性作用，了解这些结合蛋白和核受体的功能有助于我们开发具有特定作用的化合物。这篇综述总结了我们目前对类视黄醇的加工和作用方式的理解，重点介绍了类视黄醇在癌症治疗和预防中的应用。
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