天然反义转录本有什么作用？
What are natural antisense transcripts good for?
机构信息
RNA Biology Group, Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
出版信息
Biochem Soc Trans. 2010 Aug;38(4):1144-9. doi: 10.1042/BST0381144.
Abstract
NATs (natural antisense transcripts) are important regulators of eukaryotic gene expression. Interference between the expression of protein-coding sense transcripts and the corresponding NAT is well documented. In the present review, we focus on an additional, higher-order role of NATs that is currently emerging. The recent discovery of endogenous siRNAs (short interfering RNAs), as well as NAT-induced transcriptional gene silencing, are key to the proposed novel function of NATs.
摘要
NATs（自然反义转录本）是真核基因表达的重要调控因子。已有大量文献报道蛋白质编码正义转录本与相应的 NAT 之间的表达干扰。在本综述中，我们重点关注 NAT 目前新出现的一种更高级的作用。最近发现的内源性 siRNAs（短干扰 RNA）以及 NAT 诱导的转录基因沉默是 NAT 提出的新功能的关键。
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