forsythoside a 抑制细胞培养中的禽传染性支气管炎病毒。
Forsythoside a inhibits the avian infectious bronchitis virus in cell culture.
机构信息
Laboratory of Veterinary Medicine, Department of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
出版信息
Phytother Res. 2011 Mar;25(3):338-42. doi: 10.1002/ptr.3260.
Abstract
Forsythoside A is a polyphenolic constituent of the fruits of Forsythia suspensa Vahl. which is widely used as an antiinflammatory agent in traditional Chinese medicine. In the present study, the effects of forsythoside A on cell infection by avian infectious bronchitis virus were assessed. A real-time fluorescence quantitative PCR assay was used to determine mRNA content of IBV N gene. The pretreatment of cells with forsythoside A, adding forsythoside A post infection of cells, and treatment of virus with forsythoside A were analysed. The inhibitory effect of forsythoside A was confirmed by infecting primary chicken embryo kidney cells. Infected cells were inhibited by forsythoside A treatment. The data indicated that forsythoside A has the potential to prevent IBV infection in vitro. Copyright © 2010 John Wiley & Sons, Ltd.
摘要
连翘酯苷 A 是贯叶连翘果实中的一种多酚类成分，在传统中药中被广泛用作抗炎剂。在本研究中，评估了连翘酯苷 A 对禽传染性支气管炎病毒细胞感染的影响。使用实时荧光定量 PCR 法测定 IBV N 基因的 mRNA 含量。分析了连翘酯苷 A 对细胞的预处理、感染细胞后添加连翘酯苷 A 以及用连翘酯苷 A 处理病毒的效果。通过感染原代鸡胚肾细胞证实了连翘酯苷 A 的抑制作用。连翘酯苷 A 处理可抑制受感染的细胞。数据表明，连翘酯苷 A 具有体外预防 IBV 感染的潜力。版权所有 © 2010 年 John Wiley & Sons, Ltd.
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