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噬菌体 PhiX174 的生态位及其大肠杆菌脂多糖受体的灵活性。

Bacteriophage PhiX174's ecological niche and the flexibility of its Escherichia coli lipopolysaccharide receptor.

机构信息

INSERM U722 and Université Paris 7, Faculté de Médecine, Site Xavier Bichat, 16 Rue Henri Huchard, 75018 Paris, France.

出版信息

Appl Environ Microbiol. 2010 Nov;76(21):7310-3. doi: 10.1128/AEM.02721-09. Epub 2010 Sep 10.

Abstract

To determine bacteriophage PhiX174's ecological niche, 783 Escherichia coli isolates were screened for susceptibility. Sensitive strains are diverse regarding their phylogenies and core lipopolysaccharides (LPS), but all have rough phenotypes. Further analysis of E. coli K-12 LPS mutants revealed that PhiX174 can use a wide diversity of LPS structures to initiate its infectious process.

摘要

为了确定噬菌体 PhiX174 的生态位,我们筛选了 783 株大肠杆菌分离株的敏感性。敏感菌株在其系统发育和核心脂多糖 (LPS) 方面存在多样性,但均表现为粗糙表型。对大肠杆菌 K-12 LPS 突变体的进一步分析表明,噬菌体 PhiX174 可以利用多种 LPS 结构来启动其感染过程。

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