新兴碳青霉烯酶：全球视角。
Emerging carbapenemases: a global perspective.
机构信息
Cardiff University, Heath Park Hospital, UK.
出版信息
Int J Antimicrob Agents. 2010 Nov;36 Suppl 3:S8-14. doi: 10.1016/S0924-8579(10)70004-2.
Abstract
The celestial rise in antibiotic resistance among Gram-negative bacteria has challenged both the scientific and pharmaceutical sectors. The hallmark of this general increase is the unbridled dissemination of carbapenem resistance genes, namely KPC, OXA and metallo-β-lactamase variants. In particular, the media attention given to the NDM-1 metallo-β-lactamase has highlighted the global consequences of human behaviour on spreading antibiotic resistance.
摘要
革兰氏阴性菌对抗生素耐药性的普遍上升，给科学界和制药业都带来了挑战。这种普遍上升的标志是碳青霉烯类耐药基因（如 KPC、OXA 和金属β-内酰胺酶变体）的无节制传播。特别是，媒体对 NDM-1 金属β-内酰胺酶的关注，突显了人类行为对传播抗生素耐药性的全球性影响。
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