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机器人辅助根治性膀胱切除术联合体内尿流改道术的手术相关并发症。

Surgery-related complications of robot-assisted radical cystectomy with intracorporeal urinary diversion.

机构信息

Department of Molecular Medicine and Surgery, Division of Urology, Karolinska Institutet, Stockholm, Sweden.

出版信息

Urology. 2011 Apr;77(4):871-6. doi: 10.1016/j.urology.2010.11.035. Epub 2011 Jan 22.

Abstract

OBJECTIVES

To assess the surgery-related complications at robot-assisted radical cystectomy with total intracorporeal urinary diversion during our learning curve in treating 45 patients with bladder cancer.

METHODS

A total of 45 patients were pooled in 3 consecutive groups of 15 cases each to evaluate the complications according to the Clavien classification. As a surrogate for our learning curve, the following parameters were assessed: operative time, blood loss, urinary diversion type, lymph node yield, surgical margin status, and length of hospital stay.

RESULTS

Early surgery-related complications were noted in 40% of the patients and late complications in 30%. The early Clavien grade III complications remained significant (27%) and did not decline with time. Overall, fewer complications were observed between the groups over time, with a significant decrease in late versus early complications (P = .005 and P = .058). The mean operative times declined from the first group to the second and third groups (P = .005) and the hospital stays shortened (P = .006). No significant difference was observed between groups regarding the lymph node yield at cystectomy (P = .108), with a mean of 22.5 nodes (range 10-52) removed. More patients received an orthotopic bladder substitute (Studer) in each of the latter 2 groups than in the first.

CONCLUSIONS

Although robot-assisted radical cystectomy with total intracorporeal urinary diversion is a complex procedure, we observed decreased surgery-related complications and improved outcomes over time in the present series. Our results need to be confirmed by others before robot-assisted radical cystectomy with totally intracorporeal urinary diversion can be accepted as a treatment option for patients with bladder cancer.

摘要

目的

评估在我们治疗 45 例膀胱癌患者的学习曲线中,机器人辅助根治性膀胱切除术联合全腔内尿流改道的手术相关并发症。

方法

将 45 例患者分为 3 组,每组 15 例,根据 Clavien 分类评估并发症。为了评估我们的学习曲线,评估了以下参数:手术时间、出血量、尿流改道类型、淋巴结检出量、手术切缘状态和住院时间。

结果

40%的患者出现早期手术相关并发症,30%的患者出现晚期并发症。早期 Clavien Ⅲ级并发症仍然显著(27%),且并未随时间下降。总体而言,随着时间的推移,各分组之间的并发症逐渐减少,晚期并发症明显少于早期并发症(P=0.005 和 P=0.058)。手术时间从第一组到第二组和第三组逐渐下降(P=0.005),住院时间缩短(P=0.006)。各组间在膀胱切除时的淋巴结检出量方面无显著差异(P=0.108),平均检出 22.5 个淋巴结(范围 10-52 个)。在后两组中,更多的患者接受了原位膀胱替代物(Studer)。

结论

尽管机器人辅助根治性膀胱切除术联合全腔内尿流改道是一项复杂的手术,但在本研究中,我们观察到随着时间的推移,手术相关并发症减少,治疗效果改善。在机器人辅助根治性膀胱切除术联合全腔内尿流改道被接受为膀胱癌患者的治疗选择之前,我们的结果需要得到其他人的证实。

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