转录与复制：违反规则导致基因组不稳定。
Transcription and replication: breaking the rules of the road causes genomic instability.
作者信息
Poveda Ana Maria, Le Clech Mikael, Pasero Philippe
机构信息
Institute of Human Genetics, CNRS UPR, Montpelier, France.
出版信息
Transcription. 2010 Sep-Oct;1(2):99-102. doi: 10.4161/trns.1.2.12665.
Abstract
Replication and transcription machineries progress at high speed on the same DNA template, which inevitably causes traffic accidents. Problems are not only caused by frontal collisions between polymerases, but also by cotranscriptional R-loops. These RNA-DNA hybrids induce genomic instability by blocking fork progression and could be implicated in the development of cancer.
摘要
复制和转录机制在同一DNA模板上高速运行，这不可避免地会引发“交通事故”。问题不仅由聚合酶之间的正面碰撞导致，共转录R环也会引发问题。这些RNA-DNA杂交体通过阻碍复制叉前进诱导基因组不稳定，可能与癌症的发生发展有关。
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