1991-2008 年英国 0-14 岁和 15-34 岁人群 1 型糖尿病发病率趋势。

Trends in Type 1 diabetes incidence in the UK in 0- to 14-year-olds and in 15- to 34-year-olds, 1991-2008.

机构信息

Department of Public Health Sciences, King's College London, London, UK.

出版信息

Diabet Med. 2011 Jul;28(7):811-4. doi: 10.1111/j.1464-5491.2011.03288.x.

DOI:10.1111/j.1464-5491.2011.03288.x

PMID:21395679

Abstract

AIM

To describe Type 1 diabetes incidence trends in the UK between 1991 and 2008 in children aged 0-14 years and in young adults aged 15-34 years.

METHODS

Data from the UK General Practice Research Database were analysed, including 3002 individuals (1565 aged 0-14 years and 1437 aged 15-34 years) newly diagnosed with Type 1 diabetes. Poisson regression was used to model annual incidence increases and seasonality effects.

RESULTS

Type 1 diabetes incidence increased from 11 to 24/100,000 person-years in boys and from 15 to 20/100,000 person-years in girls. In adults, the incidence rate increased from 13 to 20/100,000 person-years (men) and from 7 to 10/100,000 person-years (women). Annual incidence increases tended to be greater in children (4.1%, 95% CI 3.0-5.2%) compared with 15- to 34-year-olds (2.8%, 95% CI 1.6-3.9%). There was evidence of higher incidence rates during autumn and winter in children, but not in adults.

CONCLUSIONS

A continuing increase in Type 1 diabetes incidence was shown that was greater in children than in young adults. Seasonal variation was observed in children only.

摘要

目的

描述 1991 年至 2008 年期间英国 0-14 岁儿童和 15-34 岁青年人群中 1 型糖尿病的发病趋势。

方法

分析了英国全科医生研究数据库的数据，包括 3002 名（1565 名 0-14 岁，1437 名 15-34 岁）新诊断为 1 型糖尿病的个体。采用泊松回归模型分析年度发病率增长和季节性影响。

结果

男孩 1 型糖尿病发病率从 11/100,000 人年增至 24/100,000 人年，女孩从 15/100,000 人年增至 20/100,000 人年。在成年人中，发病率从 13/100,000 人年增至 20/100,000 人年（男性）和从 7/100,000 人年增至 10/100,000 人年（女性）。儿童的年发病率增长趋势（4.1%，95%CI 3.0-5.2%）明显大于 15-34 岁人群（2.8%，95%CI 1.6-3.9%）。儿童发病存在秋季和冬季较高的证据，但在成年人中无此发现。