线粒体基因组在衰老和致癌过程中的作用。
The role of the mitochondrial genome in ageing and carcinogenesis.
作者信息
Czarnecka Anna M, Bartnik Ewa
机构信息
Laboratory of Molecular Oncology, Department of Oncology, Military Institute of Medicine, ul. Szaserów 128, 01-141 Warsaw, Poland.
出版信息
J Aging Res. 2011 Feb 15;2011:136435. doi: 10.4061/2011/136435.
Abstract
Mitochondrial DNA mutations and polymorphisms have been the focus of intensive investigations for well over a decade in an attempt to understand how they affect fundamental processes such as cancer and aging. Initial interest in mutations occurring in mitochondrial DNA of cancer cells diminished when most were found to be the same mutations which occurred during the evolution of human mitochondrial haplogroups. However, increasingly correlations are being found between various mitochondrial haplogroups and susceptibility to cancer or diseases in some cases and successful aging in others.
摘要
十多年来，线粒体DNA突变和多态性一直是深入研究的焦点，旨在了解它们如何影响诸如癌症和衰老等基本过程。当发现癌细胞线粒体DNA中发生的大多数突变与人类线粒体单倍群进化过程中出现的突变相同时，对癌细胞线粒体DNA突变的最初兴趣就减弱了。然而，越来越多的研究发现，在某些情况下，各种线粒体单倍群与癌症易感性或疾病之间存在关联，而在另一些情况下，则与成功衰老有关。
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