白色念珠菌形态发生和宿主防御：区分入侵与定植。
Candida albicans morphogenesis and host defence: discriminating invasion from colonization.
机构信息
Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.
出版信息
Nat Rev Microbiol. 2011 Dec 12;10(2):112-22. doi: 10.1038/nrmicro2711.
Abstract
Candida albicans is a common fungal pathogen of humans that colonizes the skin and mucosal surfaces of most healthy individuals. Until recently, little was known about the mechanisms by which mucosal antifungal defences tolerate colonizing C. albicans but react strongly when hyphae of the same microorganism attempt to invade tissue. In this Review, we describe the properties of yeast cells and hyphae that are relevant to their interaction with the host, and the immunological mechanisms that differentially recognize colonizing versus invading C. albicans.
摘要
白色念珠菌是一种常见的人类真菌病原体，定植于大多数健康个体的皮肤和黏膜表面。直到最近，人们对黏膜抗真菌防御机制如何耐受定植的白色念珠菌，但当同一微生物的菌丝试图侵入组织时又强烈反应的机制还知之甚少。在这篇综述中，我们描述了与宿主相互作用相关的酵母细胞和菌丝的特性，以及区分定植和侵袭性白色念珠菌的免疫学机制。
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