人肠道病毒 71 型的晶体结构。
Crystal structure of human enterovirus 71.
机构信息
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
出版信息
Science. 2012 Jun 8;336(6086):1274. doi: 10.1126/science.1218713. Epub 2012 Mar 1.
Abstract
Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the "pocket factor," a small molecule that stabilizes the virus, is partly exposed on the floor of the "canyon." Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the entrance of the pocket.
摘要
肠道病毒 71 型是一种小 RNA 病毒，与婴幼儿致命性神经疾病有关。在此，我们报道了肠道病毒 71 型的晶体结构，并表明与其他肠道病毒不同，“口袋因子”（一种稳定病毒的小分子）部分暴露在“峡谷”底部。因此，抗病毒化合物的结构可能需要一个亲水的头部基团，以与口袋入口处的残基相互作用。
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