局部递送一氧化氮：将治疗药物靶向递送至骨骼和结缔组织。
Local delivery of nitric oxide: targeted delivery of therapeutics to bone and connective tissues.
机构信息
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Adv Drug Deliv Rev. 2012 Sep;64(12):1177-88. doi: 10.1016/j.addr.2012.03.002. Epub 2012 Mar 10.
Abstract
Non-invasive treatment of injuries and disorders affecting bone and connective tissue remains a significant challenge facing the medical community. A treatment route that has recently been proposed is nitric oxide (NO) therapy. Nitric oxide plays several important roles in physiology with many conditions lacking adequate levels of NO. As NO is a radical, localized delivery via NO donors is essential to promoting biological activity. Herein, we review current literature related to therapeutic NO delivery in the treatment of bone, skin and tendon repair.
摘要
非侵入性治疗影响骨骼和结缔组织的损伤和疾病仍然是医学界面临的重大挑战。最近提出的一种治疗途径是一氧化氮（NO）治疗。一氧化氮在生理学中发挥着几个重要作用，许多情况下缺乏足够水平的 NO。由于一氧化氮是一种自由基，因此通过 NO 供体进行局部递药对于促进生物活性至关重要。本文综述了与治疗性 NO 递药治疗骨骼、皮肤和肌腱修复相关的当前文献。
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