衰老对关节软骨稳态的影响。
Effects of aging on articular cartilage homeostasis.
机构信息
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
出版信息
Bone. 2012 Aug;51(2):241-8. doi: 10.1016/j.bone.2012.03.023. Epub 2012 Mar 28.
Abstract
This review is focused on aging-related changes in cells and extracellular matrix of the articular cartilage. Major extracellular matrix changes are a reduced thickness of cartilage, proteolysis, advanced glycation and calcification. The cellular changes include reduced cell density, cellular senescence with abnormal secretory profiles, and impaired cellular defense mechanisms and anabolic responses. The extracellular and cellular changes compound each other, leading to biomechanical dysfunction and tissue destruction. The consequences of aging-related changes for joint homeostasis and risk for osteoarthritis are discussed. This article is part of a Special Issue entitled "Osteoarthritis".
摘要
这篇综述专注于关节软骨中与衰老相关的细胞和细胞外基质变化。主要的细胞外基质变化包括软骨厚度减小、蛋白水解、糖基化和钙化的进展。细胞变化包括细胞密度降低、细胞衰老伴有异常分泌谱、细胞防御机制和合成代谢反应受损。细胞外和细胞变化相互作用，导致生物力学功能障碍和组织破坏。讨论了与衰老相关的变化对关节内稳态和骨关节炎风险的影响。本文是特刊“骨关节炎”的一部分。
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