Galigniana Mario D
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales de la Universidad de Buenos Aires/INQUIBICEN and IBYME/CONICET, Buenos Aires C1428ADN, Argentina.
Chem Biol. 2012 Jun 22;19(6):662-3. doi: 10.1016/j.chembiol.2012.06.001.
In this issue of Chemistry & Biology, Grossman et al. report a study on aldosterone-dependent nuclear translocation of the mineralocorticoid receptor (MR). They analyze the dependency of MR retrotransport, DNA-binding, and transcriptional activity on Hsp90 and demonstrate that MR dimerization is a nuclear event.
在本期《化学与生物学》中,格罗斯曼等人报道了一项关于盐皮质激素受体(MR)的醛固酮依赖性核转位的研究。他们分析了MR逆向转运、DNA结合及转录活性对热休克蛋白90(Hsp90)的依赖性,并证明MR二聚化是一个核内事件。