[儿童重症社区获得性肺炎的病毒病因及危险因素]

[Viral etiology and risk factors for severe community-acquired pneumonia in children].

作者信息

Ding Xiao-Fang, Zhang Bing, Zhong Li-Li, Xiao Ni-Guang, Zhou Qiong-Hua, Duan Zhao-Jun, Xie Zhi-Ping, Gao Han-Chun

机构信息

Hunan Provincial People's Hospital, Changsha 410005, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2012 Jun;14(6):449-53.

PMID:22738454

Abstract

OBJECTIVE

To study the virus spectrum of severe community-acquired pneumonia (CAP) and risk factors for the disease in children.

METHODS

Respiratory secretion specimens were collected from 1096 children hospitalized with CAP from June 2007 to November 2008, including 100 cases of severe CAP. Respiratory viruses were detected by PCR, nest-PCR or RT-PCR. Clinical data on the children were analyzed by univariate and multivariate logistic regression analysis for examining risk factors for severe CAP.

RESULTS

Viral pathogens were isolated from 82 (82%) of the 100 cases with severe CAP. RSV was the most common (37%), followed by HBoV (25%) and HRV (18%). Mixed infection was noted in 32 cases (32%). The presence of underlying diseases (OR=6.623, P<0.01) and RSV infection (OR=1.672, P<0.05) were risk factors for severe CAP in children, while age was a protective factor (OR=0.475, P<0.01).

CONCLUSIONS

RSV is the most frequent viral pathogen in children with severe CAP. The presence of underlying diseases and RSV infection may be risk factors for severe CAP, while age is a protective factor.

摘要

目的

研究儿童重症社区获得性肺炎（CAP）的病毒谱及该病的危险因素。

方法

收集2007年6月至2008年11月期间因CAP住院的1096例儿童的呼吸道分泌物标本，其中包括100例重症CAP患儿。采用PCR、巢式PCR或RT-PCR检测呼吸道病毒。对患儿的临床资料进行单因素和多因素逻辑回归分析，以检验重症CAP的危险因素。

结果

100例重症CAP患儿中，82例（82%）分离出病毒病原体。呼吸道合胞病毒（RSV）最为常见（37%），其次是博卡病毒（HBoV，25%）和人鼻病毒（HRV，18%）。32例（32%）存在混合感染。基础疾病的存在（OR=6.623，P<0.01）和RSV感染（OR=1.672，P<0.05）是儿童重症CAP的危险因素，而年龄是保护因素（OR=0.475，P<0.01）。